Curriculum vitae

Education:

     1976 BSc. Hons., Botany, Liverpool England
     1978 M. Phil., Applied Biology, Cambridge University, England
     1991 Ph.D., Cell and Molecular Biology, University of Nevada, Reno

Research Positions:

1976-1977 Scientific Officer, Analytical Chemistry. Ministry of Agriculture, Fisheries and Food, Cambridge, England
1978-1979 Research Associate, Botany, University of Cambridge, England
1980 Research Associate, Dept. Biology, University of California, San Diego & Research Technician Salk Institute, San Diego
1980-1981 Research Associate, Dept. Biology, University of California, San Diego
1981-1984 Research Associate, Dept. Neurosciences, University of California, San Diego
1984-1987 Research Associate, Dept. Microbiology, University of Nevada, Reno
1987-1989 Research Associate, Dept. Pharmacology, University of Nevada, Reno
1991-2000 Research Assistant Professor, Dept. Pharmacology, University of Nevada, Reno
2000-2007 Associate Professor, Dept. Pharmacology, University of Nevada, Reno

Professional Experience:

Member Biophysical Society
Study Section member, American Heart Association, Western Affiliate 1998-2002
Reviewer, Merit Review Awards, Office of External Reviews, Dept of Veterans Affairs
Reviewer Idaho and Nevada INBRE's (NIH)

Ad Hoc Reviewer:

Biotechniques
Circulation
Archives of Biochemistry and Biophysics
American Journal of Physiology
American Journal of Applied Physiology
Journal of Cell Science
Journal of Molecular and Cellular Cardiology
Protein Expression and Purification
Journal of Applied Physiology
Journal of Biological Chemistry
EMBO J
Experimental Hematology
Circulation

Publications:

      Ariyasu, R.G., J.A. Nichol (Airey) and M.H. Ellisman. (1985) Localization of Sodium/Potassium Adenosine Triphosphatase in multiple cell types of the murine nervous system with antibodies raised against the enzyme from kidney. J. Neurosci. 5:2581-2590
      Hatton, J.D., G.F. Cox, A.L. Miller, J.A. Nichol (Airey) and M.H. Ellisman. (1987) Identification of polypeptides associated with the sarcolemmal orthogonal array. Biochem. Biophys. Acta 904:373-381
      Airey, J.A., C.F. Beck, S.J. Tanksley, T.J. Deerinck, M.H. Ellisman and J.L. Sutko. (1990) Identification and localization of foot protein isoforms in avian fast twitch skeletal muscle. J. Biol. Chem. 265:14187-14194
      Ellisman, M., T. Deerinck, Y. Ouyang, C.F. Beck, S. Tanksley, P. Walton, J.A. Airey, and J.L. Sutko. (1990) Identification of ryanodine binding proteins in the avian central nervous system. Neuron 5:135-146
      Airey, J.A., M.J. Rodgers and J.L. Sutko. (1991) Quantitative electrophoretic transfer of high molecular weight proteins from polyacrylamide gels cross-linked with DHEBA. Biotechniques 10:605-606
      Sutko, J.L., J.A. Airey, K. Murakami, C.F. Beck, S. Tanksley, M. Takeda, T.J. Deerinck and M.H. Ellisman. (1991) Expression of alpha and beta isoforms during embryonic development of avian skeletal muscle. J. Cell Biol. 113:793-803
      Olivares, E., S.J. Tanksley, J.A. Airey, C.F. Beck, T. Deerinck, M.H. Ellisman and J.L. Sutko. (1991) Multiple foot protein isoforms in amphibian, avian and piscine skeletal muscle. Biophys. J. 59:1153-1163
      Walton, P.D., J.A. Airey, J.L. Sutko, C.F. Beck, G.A. Mignery, T.C. Südhof, T.J. Deerinck and M.H. Ellisman. (1991) Ryanodine and 1,4,5 inositol trisphosphate receptors co-exist in avian cerebellar Purkinje neurons. J. Cell Biol. 13:1145-1157
      Airey, J.A., M.D. Baring and J.L. Sutko (1991) Ryanodine receptor protein is expressed during differentiation in the muscle cell lines BC3H1 and C2C12. Dev. Biol. 148:365-374
      Zupanc, G.K.H., J.A. Airey, L. Maler, J.L. Sutko and M.H. Ellisman. (1992) Immunohistochemical localization of ryanodine binding proteins in the central nervous system of gymnotiform fish. J. Comp. Neurol. 325:135-151
      Dutro, S.M., J.L. Sutko, C.F. Beck, J.A. Airey and W.R. Trumble. (1993) The junctional foot protein during development of avian cardiac muscle. Dev. Biol. 155:431-441
      Chen, S.R.W., D.M. Vaughan, J.A. Airey, R. Coronado and D.H. MacLennan. (1993) Functional expression of cDNA encoding the Ca2+ release channel (ryanodine receptor) of rabbit skeletal muscle sarcoplasmic reticulum in COS-1 cells. Biochemistry 32:3743-3853
      Ouyang, Y., T.J. Deerinck, P.D. Walton, J.A. Airey, J.L. Sutko and M.H. Ellisman. (1993) Distribution of ryanodine receptors in the chicken central nervous system. Brain Res. 620:269-280
      Airey, J.A., M.M. Grinsell, L.R. Jones, J.L. Sutko and D. Witcher. (      Ivanenko, A., M.D. Baring, J.A. Airey, J.L. Sutko and J.L. Kenyon (1993) A caffeine- and ryanodine-sensitive Ca2+ store in avian sensory neurons. J. Neurophysiol. 70:710-716
      Airey, J.A., M.D. Baring, C.F. Beck, Y. Chelliah, T.J. Deerinck, M.H. Ellisman, L.D. Houenou, D.D. McKemy, J.L. Sutko and J. Talvenheimo. (1993) Failure to make normal a ryanodine receptor is an early event associated with the crooked neck dwarf (cn) mutation in chicken. Dev.      Airey, J.A., T.J. Deerinck, M.H. Ellisman, L.D. Houenou, A. Ivanenko, J.L. Kenyon, D.D. McKemy and J.L. Sutko (1993) Crooked neck dwarf (cn) mutant chicken skeletal muscle cells in low density primary cultures fail to express normal a ryanodine receptor and exhibit a partial mutant phenotype. Dev. Dynam. 197:189-202
      Chen, S.R.W., J.A. Airey and D.H. MacLennan. (1993) Positioning of major tryptic fragments in the Ca2+-release channel (ryanodine receptor) resulting from partial digestion       Welch, W.R., S. Ahmad, J.A. Airey, K. Gerzon, R.A. Humerickhouse, H.R. Besch, Jr., L. Ruest, P. Deslongchamps and J.L. Sutko. (1994) Structural determinants of high-affinity binding of ryanoids to the vertebrate skeletal muscle ryanodine receptor: A comparative molecular field analysis. Biochemistry 33:6074-6085
      Percival, A.L., A.J. Williams, J.L. Kenyon, M.M. Grinsell, J.A. Airey and J.L. Sutko. (1994) Chicken skeletal muscle ryanodine receptor isoforms: Ion channel properties. Biophys. J. 67:1834-1850
      Ivanenko, A., D.D. McKemy, J.L. Kenyon, J.A. Airey and J.L. Sutko. (1995) Embryonic chicken skeletal muscle cells fail to develop normal coupling in the absence of the a ryanodine receptor: Implications for a two-ryanodine receptor system. J. Biol. Chem. 270:420-4223
      Kenyon, J.L., D.D. McKemy, J.A. Airey and J.L. Sutko (1995) Interaction between ryanodine receptor function and sarcolemmal Ca2+ currents. Am. J. Physiol. 269:C334-C340
      Tinker, A., J.L. Sutko, L. Ruest, P. Deslongchamps, W.H. Welch, J.A. Airey, K. Goerzon, K.R. Bidasee, H.R. Besch Jr. and A.J. Williams. (1996) Electrophysiological effects of ryanodine derivatives on the sheep cardiac sarcoplasmic reticulum calcium-release channel. Biophys. J.       Welch, W., J.L. Sutko, K.E. Mitchell, J. Airey and L.Ruest. (1996) The pyrrole locus is the major orienting factor in ryanodine binding. Biochemistry 35:7165-7173
      Castellani, L., M. Reedy, J.A. Airey, R. Gallo, M.T. Ciotti, G. Falcone and S. Alemà. (1996) Remodelling of cytoskeleton and triads following activation of v-Src tyrosine kinase in quail myotubes. J. Cell Science 109:1335-1346
      Welch, W.H., A.J. Williams, A. Tinker, K.E. Mitchell, P. Deslongchamps, J. Lamothe, K. Gerzon, K.R. Bidasee, H.R. Besch Jr, J.A. Airey, J.L. Sutko and L. Ruest. (1997) Structural components of ryanodine responsible for ligand binding and modulation of calcium channel function. Biochemistry 36:2939-2950
      Martone, M.E., S.A. Alba, J.A. Airey and M.H. Ellisman. (1997) Distribution of Inositol 1,4,5 Trisphosphate and Ryanodine Receptors in Rat Neostriatum. Brain Res. 756:9-21
      Ouyang, Y., M.E. Martone, T.J. Deerinck, J.A. Airey, J.L. Sutko and M.H. Ellisman. (1997) Differential distribution subcellular localization of ryanodine receptor isoforms in the chicken cerebellum during development. Brain Res. 775:52-62
      Lesh, R.E., G.F. Nixon, S. Fleischer, J.A. Airey, A.P. Somlyo and A.V. Somlyo. (1998) Localization of ryanodine receptors in smooth muscle. Circ. Res. 82:175-185
      McKemy, D.D., W. Welch, J.A. Airey and J.L. Sutko. (2000) Concentrations of caffeine greater than 20 mM increase the ratio of Indo-1 fluorescence ration in a Ca2+ independent manner. Cell Calcium, 27:117-124
      Peng, S., N.G. Publicover, J.A. Airey, J.E. Hall, H.T. Haigler, J. Zhang, S.R.W. Chen and J.L. Sutko. (2004) Imaging of single cardiac of ryanodine receptor Ca2+ fluxes in lipid bilayers. Biophysical J. 86:134-144
      Peng, S., N.G. Publicover, G.J. Kargacin, D. Duan, J.A. Airey and J.L. Sutko. (2004) Diffusion of single ryanodine receptors in lipid bilayers is decreased by annexin 12. Biophysical J. 86:145-151
      Airey, J.A., G. Almeida-Porada, E.J. Colletti, C.D. Porada, J. Chamberlain, M. Movsesian, J.L. Sutko and E.D. Zanjani. (2004) Human mesenchymal stem cells form Purkinje fibers in fetal sheep heart. Circulation, 109:1401-1407
      Kögler, G., S. Sensken, J. Airey, T. Trapp, M. Muschen, N. Feldhahn, S. Liedtke, R.V. Sorg, J. Fischer, C. Rosenbaum, S. Greschat, A. Knipper, J. Bender, O. Degistirici, J. Gao, A.I. Caplan, E.J. Colletti, G. Almeida-Porada, H.W. Muller, E. Zanjani and P. Wernet. (2004) A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential. J Exp Med 200:123-135
      Colletti,E.J., G. Almeida-Porada, J. Chamberlain, E.D. Zanjani, J.A. Airey. (2006) The Time Course of Engraftment Of Human Mesenchymal Stem Cells In Fetal Heart Demonstrates That Purkinje Fiber Aggregates Derive From A Single Cell And Not Multi-Cell Homing. Exp. Hematol. 34:926-933

Invited reviews:

Sutko, J.L. and J.A. Airey. (1996) Ryanodine receptor Ca2+ release channels: does diversity in form equal diversity in function? Physiol. Rev. 76:1027-1071
Sutko, J.L., J.A. Airey, W. Welch and L. Ruest. (1997) The pharmacology of ryanodine and related compounds. Pharm. Rev. 49:53-98

Book chapter:

Airey, J.A. and R. He. (1998) Ryanodine receptor phosphorylation. In Structure and function of ryanodine receptors. R. Sitsapesan and A.J. Williams, eds, Imperial College Press, London England, pp 137-158.

Teaching Experience:

Medical Pharmacology
For medical students, various topics such as treatment of hyperlipidemias, hypertension and pharmacokinetics including both lectures, and clinical problem solving with small groups.
Cellular & Molecular Pharmacology
For graduate students, various topics such as molecular techniques, cell signaling and calcium signaling including calcium channels
Cellular & Molecular Mechanisms of Excitability
For undergraduate students, basic cell biology

Graduate Student Thesis Committees:

Kathy Mitchell - Biochemistry, Graduated 1997
Tejal Bhat - Cell & Mol Biol, Graduated 1997
Rong He - Cell & Mol Phys & Pharm, Graduated 1998*
David McKemy - Cell & Mol Phys & Pharm, Graduated 1999
Sherri Bloomer - Cell & Mol Biol, Graduated 1999
Lindsay Lannon - Audiology & Speech Pathology, Graduated 2001
Evan Colletti – Cell & Mol Biol, Graduated 2006

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